Surgical Oncology Research

Laboratory Researcher

Leaders in Cancer Research

Basic and Translational Research

Surgical oncology faculty members are involved in significant basic science and translational laboratory research programs, supported by the National Institutes of Health and a variety of other funding agencies. The types of cancer research conducted here include:

  • Study the role of irreversible electroporation in the treatment of locally advanced pancreatic cancer
  • Study the role of naturally occurring chemopreventive agents in gastroesophageal cancer
  • Study the role of alcohol-mediated hepatocellular cancer
  • Development of a large prospective hepatico-pancreatico-biliary, gastric and esophageal, sarcoma, breast, endocrine (parathyroid, thyroid, adrenal), hepatic arterial, soft tissue ablation, and melanoma database
  • Adenovirus-mediated oncolytic therapy
  • Novel agents for sentinel lymph node biopsy
  • Development of novel adenoviral vector gene therapy treatments for cancer
  • Genetic studies of melanoma, breast, thyroid, GI, and lung cancers
  • Innovative studies to explore how nipple aspirate fluid might hold the key to early breast cancer detection and to determine molecular markers of the best response to chemotherapy
  • Studies of lymphangiogenesis in melanoma
  • Studies to evaluate patient decision-making in breast, lung, and colorectal cancer
  • Molecular staging of melanoma
  • Investigation of oxidative stress in the progression of Barrett's esophagus to adenocarcinoma
  • Nanoparticles and thyroid cancer
  • The role of estrogen in thyroid cell proliferation
  • The role of ethnic background in thyroid cancer
  • Studies evaluating the impact of psychological and physiological stress on breast cancer
  • Laboratory-based studies evaluating the impact of smoking on breast cancer development
  • Collaborative work evaluating the impact of diet on estrogen metabolism in breast cancer
  • Studies evaluating methods of tailoring therapy for breast cancer patients
  • Studies evaluating accelerated partial breast radiation in breast cancer
  • Optimization of digestive enzyme mixtures to achieve maximum recovery of islet cells during isolation from pancreases

Clinical Trials

The Division of Surgical Oncology has directed more than 75 clinical studies, involving more than 14,000 patients, including national multicenter cancer studies directed by members of the Division.

Faculty members:

McMasters, Flynn, Martin, Scoggins, Polk

Laboratory Investigators:

H. Sam Zhou, X-Mei Rao, Pei Hsin (Penny) Cheng, Lan Chen, Hongying Hao, Jorge G. Gomez-Gutierrez Yan Li, Xinqin Kang, Deyi Xiao