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Liver Cancer

Liver cancer is a malignant tumor that may cause jaundice (yellow skin and eyes), pain, weight loss, or remain asymptomatic. It has a very aggressive growth pattern and must be treated by experienced physicians. Liver cancer requires a coordinated treatment plan that sometimes includes surgery, chemotherapy and radiation therapy. Many liver cancers arise (start) from the liver, including hepatocellular carcinoma and cholangiocarcinoma.

Metastatic Cancer to the Liver

Many cancers spread (metastasize) to the liver. The most common is colorectal cancer. By definition, if a cancer has spread to the liver, it is an advanced cancer. Treatment of metastatic cancer to the liver requires a team approach that involves experienced liver surgeons who understand not only how to do the surgery, but also have a deep understanding of the biology of the tumor and have the input and support from the medical and radiation oncologists.

Special therapies for metastatic cancer to the liver offered by the Division of Surgical Oncology:

  • Liver resection, laparoscopic liver resection, tumor ablation.
  • Extended lymph node dissection
  • Preoperative chemotherapy and radiation for tumor downstaging (shrinking)
  • Trans-arterial chemoembolization.
  • SIR-spheres and Theraspheres - the region's only center to deliver these forms of internal radiation to treat liver tumors.
  • Intraoperative MRI-guided ablation of liver tumors.
  • Hepatic artery chemotherapy pump placement.

Research protocols currently open for metastatic cancer to the liver:

  • Outcomes in surgical oncology
  • Cell-saver autotransfusion in surgical oncology
  • Biobanking of tumor tissue for molecular research
  • Compassionate use of Theraspheres.

Treatment for Advanced Liver Tumors

We offer a multidisciplinary approach to managing advanced unresectable liver tumors that includes a combination of chemotherapy, chemoembolization, radioembolization, and ablation techniques to increase survival while maximizing quality of life.

Research protocols currently open for metastatic cancer to the liver:

  • Outcomes, combination chemoembolization and infusion chemotherapy for metastatic colon cancer
  • Combination chemoembolization and infusion chemotherapy for unresectable bile duct cancer
  • Biobanking of tumor tissue for molecular research
  • Irreversible Electroporation of liver tumors.

Physicians who treat Liver Cancer:

Robert C.G. Martin, II, M.D., Ph.D.

Robert C.G. Martin, II, M.D., Ph.D.
Clinics and times
UofL Physicians-Surgery office, 601 South Floyd, Suite 710 -- Monday mornings
James G. Brown Cancer Center -- 1st and 3rd Monday afternoons
Norton Medical Plaza, Old Brownsboro Crossing -- 2nd and 4th Monday afternoons
Clinic Contact: Traci Hayat 583-8303

Kelly M. McMasters, M.D., Ph.D.

Kelly M. McMasters, M.D., Ph.D.
Clinics and times
UofL Physicians-Surgery office, 601 South Floyd, Suite 710 -- Friday mornings
James G. Brown Cancer Center -- Tuesday mornings
Clinic Contact: Pam Boone 583-8303

Prejesh Philips, M.D.

Prejesh Philips, M.D.

Charles R. Scoggins, M.D., M.B.A.

Charles R. Scoggins, M.D., M.B.A.
Clinics and times
UofL Physicians-Surgery office, 601 South Floyd, Suite 710 -- Monday mornings
James G. Brown Cancer Center -- 1st and 3rd Monday afternoons
Norton Medical Plaza, Old Brownsboro Crossing -- 2nd and 4th Monday afternoons
Clinic Contact: Traci Hayat 583-8303


Special therapies for liver cancer offered by the Division of Surgical Oncology:

  • Liver resection, laparoscopic liver resection, tumor ablation.
  • Extended lymph node dissection
  • Preoperative chemotherapy and radiation for tumor downstaging (shrinking)
  • Trans-arterial chemoembolization.
  • SIR-spheres and Theraspheres - the region's only center to deliver these forms of internal radiation to treat liver tumors.
  • Intraoperative MRI-guided ablation of liver tumors.

Research protocols currently open for liver cancer:

  • Outcomes in surgical oncology
  • Cell-saver autotransfusion in surgical oncology
  • Biobanking of tumor tissue for molecular research
  • Compassionate use of Theraspheres.
  • Theraspheres for unresectable hepatocellular carcinoma.
  • Multimodality treatment of advanced unresectable hepatocellular cancer involving radiation therapy, chemotherapy and surgical therapy.